Pressure Sensing of Lysosomes and Its Impact on TFEB Responses in Macrophages

Friday, 12 July 2024, 09:21

This post discusses how lysosomes in macrophages sense pressure, affecting the TFEB response. The study reveals that lysosomal mechanosensitive channels play a crucial role in regulating mTORC1, TFEB/TFE3 activation, and release of monocyte chemoattractant proteins. Understanding this pressure-sensing pathway on lysosomes offers insights into lysosomal biogenesis and myeloid cell recruitment with potential implications in various tissues.

Nature — Pressure Sensing of Lysosomes and Its Impact on TFEB Responses in Macrophages

Pressure Sensing of Lysosomes in Macrophages:

Overview

Macrophages utilize a pressure-sensing mechanism in lysosomes that affects TFEB responses.

Key Findings

Lysosomal Channels: Mechanosensitive channels in lysosomes cause a cation leak under hydrostatic pressure.
mTORC1 Inhibition: Pressure-sensitive channels inhibit mTORC1 activation, leading to TFEB/TFE3 activation.
Monocyte Recruitment: The process results in the release of monocyte chemoattractant proteins.

This study sheds light on the interplay between lysosome pressure sensing and cellular responses, offering new insights into lysosomal dynamics and myeloid cell functions.

This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.