Ichnos Glenmark Innovation Shares Phase I Study Results for Myeloma Treatment

Tuesday, 5 November 2024, 20:31

Ichnos Glenmark Innovation has announced that it will present compelling data from its Phase I study for ISB 2001, a drug candidate aimed at treating myeloma. The data will be showcased at the 66th ASH Annual Meeting, focusing on its first-in-class mechanism targeting myeloma cells. With promising early results, including a significant response rate, this study marks a pivotal moment in myeloma treatment advancements.
Financialexpress
Ichnos Glenmark Innovation Shares Phase I Study Results for Myeloma Treatment

Ichnos Glenmark Innovation Presents Groundbreaking Phase I Study Data

Ichnos Glenmark Innovation (IGI) on Wednesday announced that it will present first-time data from its Phase 1 study of ISB 2001 in an oral presentation at the 66th American Society of Hematology (ASH) Annual Meeting in San Diego, CA. According to the company's statement, ISB 2001 is IGI's first-in-class trispecific antibody targeting BCMA and CD38 on myeloma cells and CD3 on T cells, currently investigated in relapsed/refractory multiple myeloma (r/r MM).

“Although recent advancements have brought new therapeutic options to multiple myeloma patients, resistance mechanisms continue to limit their efficacy, necessitating multiple lines of treatment for many patients,” said Lida Pacaud, M.D., Chief Medical Officer at IGI. “We are encouraged by the early data from our Phase 1 study of ISB 2001, which shows a remarkable response rate and demonstrates potential to address these challenges in heavily pretreated patients.”

Key Findings from the Phase 1 Study

  • An overall response rate (ORR) of 75% (9/12) in efficacy-evaluable patients, including one (1) MRD negative stringent complete response (sCR).
  • A favorable safety and tolerability profile that showed no dose-limiting toxicities (DLTs), only one adverse event of special interest (AE) above Grade 2, and no treatment discontinuation.

The oral presentation at ASH will be supplemented with additional data and analyses, it added.


This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.


Related posts


Newsletter

Subscribe to our newsletter for the most accurate and current medical news. Stay updated and deepen your understanding of medical advancements effortlessly.

Subscribe