Exploring the Impact of Surgery on Aging and Cognitive Function
Study Highlights on Surgery and Brain Health
WEDNESDAY, Oct. 9, 2024 (HealthDay News) -- Surgeries are generally safe but cumulatively are associated with cognitive decline and neurodegeneration. This finding emerges from a study published in the September issue of The Lancet Healthy Longevity. Conducted by Jennifer Taylor, Ph.D., from the University of Sydney, the research analyzed major surgical and medical hospital admissions in older individuals aged 40 to 69 years.
Cognitive Function Assessment
The study included an extensive cohort of 492,802 participants from the U.K. Biobank, with 46,706 undergoing magnetic resonance imaging. Researchers noted small yet significant adverse effects on cognition per surgery in fully adjusted models:
- Reaction time increased by 0.273 ms
- Fluid intelligence scores decreased by 0.057 correct responses
- Prospective memory declined (odds ratio, 0.96)
- Numeric memory maximum correct matches decreased by 0.025
Neurodegeneration and Brain Volume Changes
Additionally, there were notable associations between surgical procedures and reduced hippocampal volume (β = -5.76 mm3) and increased white matter hyperintensities volume (β = 100.02 mm3) in fully adjusted models. These findings point to neurodegeneration effects in the insula and superior temporal cortex linked to surgeries.
This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.