Higher Depression Genetic Burden and Multiple Sclerosis Disease Activity

Wednesday, 2 October 2024, 17:02

Higher depression genetic burden significantly correlates with multiple sclerosis disease activity. Recent findings emphasize the role of depression polygenic score (DPS) in increasing relapse risk and worsening disability in MS patients. This research provides essential insights into the risk factors affecting mental health in multiple sclerosis.
Physiciansweekly
Higher Depression Genetic Burden and Multiple Sclerosis Disease Activity

Higher Depression Genetic Burden Impacts MS

A recent Canadian study highlights a compelling association between higher depression genetic burden and increased activity in multiple sclerosis. The research indicates that those with a higher depression polygenic score (DPS) experience worsening disability and a greater relapse risk, dismissing reverse causality as a contributing factor. Understanding these links is critical for improving mental health management in MS patients.

Research Insights

  • Depression Genetic Variant: The study identified specific genetic variants that may exacerbate MS symptoms.
  • Efficacy and Safety: The results underline the importance of monitoring mental health as part of MS treatment protocols.

Conclusion on Mental Health in MS

Given the findings, healthcare providers should prioritize screening for depression in patients with multiple sclerosis to better manage relapse risks and overall quality of life.


This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.


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