Understanding Oral Cancer's Immune Evasion: The Role of STAT3 and EGFR
Research Findings on Immune Evasion in Oral Cancer
Researchers at Macquarie University have made a significant breakthrough in understanding how oral cancer cells evade the body's immune system. This discovery could lead to the development of more effective treatments for this aggressive disease.
The Role of STAT3 in Oral Cancer
The study, published in the Journal of Oral Biosciences, investigated the interactions between proteins in oral cancer cells that prevent immune cells from attacking the tumors. Lead author Dr Rajdeep Chakraborty emphasizes that proteins like STAT3 play a pivotal role in immune evasion.
Key Protein Interactions
- STAT3 and its partners may act as camouflage for cancer cells.
- A protein called EGFR was found closely linked to STAT3 in oral cancer cells.
- Research employed a patented three-dimensional cancer model to study protein interactions.
Implications for Immunotherapy
This new research sheds light on potential new drug targets that could help enhance the immune response against oral cancer cells, particularly in the context of overcoming drug resistance.
This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.