Athira Shifts Focus to ALS Drug Following Alzheimer’s Trial Flop

Wednesday, 18 September 2024, 05:14

Athira Pharma shifts focus to ALS drug ATH-1105 after Alzheimer’s treatment fosgonimeton failed in LIFT-AD trial. The company plans to cut 70% of its workforce, aiming to save $13.4 million. This strategic pivot highlights the challenges and opportunities within neurodegenerative disease research.
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Athira Shifts Focus to ALS Drug Following Alzheimer’s Trial Flop

Overview of Athira Pharma's Transition

Athira Pharma has made significant changes in its research focus. After the disappointing results from its Alzheimer’s drug fosgonimeton in the LIFT-AD trial, the company is shifting its attention to developing ATH-1105, an ALS treatment. This strategic decision also includes a substantial workforce reduction, aiming to streamline operations and focus resources efficiently.

Impact of the Alzheimer’s Trial Results

  • The LIFT-AD trial did not meet its endpoints, leading to reevaluation of drug development strategies.
  • Athira plans to cut approximately 70% of its workforce to conserve resources.
  • Expected savings from the layoffs are projected to be around $13.4 million.

Looking Ahead: The ALS Drug Development

Athira's renewed focus on ATH-1105 represents a critical pivot towards addressing unmet medical needs in ALS treatment. The healthcare community is keenly observing this transition as it could potentially lead to breakthroughs in the neurodegenerative sector.


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