Amivantamab Combination Treatment for Metastatic Colorectal Cancer: Phase 1b/2 Results

Saturday, 14 September 2024, 14:39

Amivantamab has shown promising results in treating metastatic colorectal cancer. The recent Phase 1b/2 OrigAMI-1 study highlights its efficacy when combined with chemotherapy for patients with RAS/BRAF wild-type metastatic colorectal cancer.
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Amivantamab Combination Treatment for Metastatic Colorectal Cancer: Phase 1b/2 Results

Amivantamab and Its Impact on Colorectal Cancer

In recent findings from the Phase 1b/2 OrigAMI-1 study, research led by Janssen-Cilag International NV reveals that amivantamab, in combination with chemotherapy regimens such as mFOLFOX6 and FOLFIRI, displays promising rapid and durable antitumor activity in patients diagnosed with RAS/BRAF wild-type metastatic colorectal cancer.

Study Highlights

  • The combination treatment showcased significant efficacy in reducing tumor size.
  • Patients experienced favorable safety profiles.
  • Long-term outcomes indicate potential for improved survival rates.

Next Steps

As researchers anticipate further trials, the implications of this study open new avenues for combination therapies in colorectal cancer treatment, affirming amivantamab as a notable option going forward.


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This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.


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