Exploring Multivariate Associations Between Neuroanatomy and Cognition in Schizophrenia
Sunday, 14 July 2024, 09:36
Study Objective
Previous research on neuroanatomy-cognition links in schizophrenia presents inconsistent findings, especially with the impact of medication.
Methods and Samples
A study involving drug-naïve individuals with first-episode schizophrenia and antipsychotic-treated individuals examined multivariate associations between cognitive domains and neuroanatomic features.
Key Findings
- Unmedicated Group: Token motor, symbol coding, and verbal fluency performance correlated with thalamic volumes and cortical thickness variations in specific brain regions.
- Medicated Group: Verbal memory and symbol coding performance linked to subcortical structures and cortical surface area differences.
Implications
Distinct multivariate patterns were identified, offering insights into the neurobiological underpinnings of cognitive deficits in individuals with schizophrenia.
This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.